| 货号 | 19577-1mg |
| 描述 | Sauchinone is a lignan first isolated from the aerial parts of S. chinensis, a plant used in Asian medicine for its anti-inflammatory, anti-angiogenic, and anti-nociceptive activities.1 Sauchinone has numerous effects on isolated cells, including blocking NF-κB activation in LPS-stimulated macrophages, inducing heme oxygenase-1 transcription in endothelial cells, and attenuating oxidative-stress-induced damage in myoblasts.2,3,4 Sauchinone is extensively metabolized in vivo, but intraperitoneal administration significantly reduces myocardial infarct size induced by ischemia/reperfusion in mice.5,6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Yoo, H.J.,Kang, H.J.,Jung, H.J., et al. Anti-inflammatory, anti-angiogenic and anti-nociceptive activities of Saururus chinensis extract. J.Enthopharmacol. 120(2), 282-286 (2008). 2.Lee, A.K.,Sung, S.H.,Kim, Y.C., et al. Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-α and COX-2 expression by sauchinone effects on I-κBα phosphorylation, C/EBP and AP-1 activation. British Journal of Pharmacology 139, 11-20 (2003). 3.Li, B.,Lee, Y.J.,Kim, Y.C., et al. Sauchinone from Saururus chinensis protects vascular inflammation by heme oxygenase-1 induction in human umbilical vein endothelial cells. Phytomedicine 21(2), 101-108 (2014). 4.Jung, M.H.,Song, M.C.,Bae, K., et al. Sauchinone attenuates oxidative stress-induced skeletal muscle myoblast damage through the down-regulation of ceramide. Biological and Pharmaceutical Bullentin 34(4), 575-579 (2011). 5.Kim, S.J.,Jeong, C.W.,Bae, H.B., et al. Protective effect of sauchinone against regional myocardial ischemia/reperfusion injury: inhibition of p38 MAPK and JNK death signaling pathways. J.Korean Med.Sci. 27(5), 572-575 (2012). 6.Kim, Y.J.,Han, S.Y.,Seo, J.S., et al. Pharmacokinetics, tissue distribution, and tentative metabolite identification of sauchinone in mice by microsampling and HPLC-MS/MS methods. Biological and Pharmaceutical Bullentin 38(2), 218-227 (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 356.4 |
| 分子式 | C20H20O6 |
| CAS号 | 177931-17-8 |
| 稳定性 | ≥ 2 years |
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