SR 0987
货号：
19503-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19503-1mg |
| 描述 | SR 0987 is an agonist of the T cell-specific isoform of RORγ (RORγt, retinoic acid receptor-related orphan receptor-γt), inducing reporter gene expression with an EC50 value of ~800 nM.1 Stimulation of mouse EL4 T lymphocytes with SR 0987, following activation with PMA (Item No. 10008014) and ionomycin (Item No. 10004974), increases expression of the RORγt target IL-17, while expression of the programmed cell death protein PD-1 is decreased and granzyme B is unchanged.1 Decreased cell surface PD-1 protein, assessed by flow cytometry, is observed in a variety of T cells treated with SR 0987.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Chang, M.R.,Dharmarajan, V.,Doebelin, C., et al. Synthetic RORγt Agonists Enhance Protective Immunity. ACS Chemical Biology 11(4), 1012-1018 (2016).
|
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 397.7 |
| 分子式 | C16H10ClF6NO2 |
| CAS号 | 303126-97-8 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
