PF-04457845
货号：
19306-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19306-1mg |
| 描述 | PF-04457845 is an orally active, irreversible inhibitor of fatty acid amide hydrolase (FAAH; IC50 = 7.2 nM) that is selective against other serine hydrolases.1 It is a covalent inhibitor that carbamylates the active site serine nucleophile of FAAH.1 In a rat model of inflammatory pain, oral administration of 0.1 mg/kg PF-04457845 has been shown to reduce inflammatory pain with efficacy comparable to that of naproxen.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Johnson, D.S.,Stiff, C.,Lazerwith, S.E., et al. Discovery of PF-04457845: A highly potent, orally bioavailable, and selective urea FAAH inhibitor. ACS Med.Chem.Lett. 2(2), 91-96 (2011).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 455.4 |
| 分子式 | C23H20F3N5O2 |
| CAS号 | 1020315-31-4 |
| 稳定性 | ≥ 2 years |
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