XMD8-92
货号：
19173-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19173-1mg |
| 描述 | XMD8-92 is an ERK5 inhibitor (Kd = 80 nM) that less potently inhibits DCAMKL2, TNK1, and Plk4 (Kds = 190, 890, and 600 nM, respectively), from a panel of 402 different tested kinases.1 It blocks ERK5 autophosphorylation, ERK5-mediated phosphorylation of promyelocytic leukemia protein (PML), and PML-dependent activation of p21.1 XMD8-92 suppresses tumor cell proliferation in vitro and tumor growth and angiogenesis in vivo.1 XMD8-92 inhibits AP-1 transcriptional activity induced by MEK5-activated ERK5 but not that induced by Cdc37.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Yang, Q.,Deng, X.,Lu, B., et al. Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein. Cancer Cell 18(3), 258-267 (2010).
2.Erazo, T.,Moreno, A.,Ruiz-Babot, G., et al. Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex. Mol.Cell Biol. 33(8), 1671-1686 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 474.6 |
| 分子式 | C26H30N6O3 |
| CAS号 | 1234480-50-2 |
| 稳定性 | ≥ 2 years |
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