BMX-IN-1
货号：
19165-500ug 基本售价：
350.0 元 规格：
500 ug
产品信息
概述| 货号 | 19165-500ug |
| 描述 | BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX; IC50 = 8 nM) that targets Cys496 in the BMX ATP binding domain.1 It additionally targets the related Bruton’s tyrosine kinase (BTK) with an IC50 value of 10.4 nM, but is more than 47-656-fold less potent for inhibition of Blk, JAK3, EGFR, Itk, or Tec activity. BMX-IN-1 was shown to inhibit the proliferation of Tel-BMX-transformed Ba/F3 prostate cancer cells with a GI50 value of 25 nM.1 Antiproliferative activity was also observed in RV-1, DU-145, PC-3, and VCAP prostate cancer cell lines (GI50s = 2.54, 4.38, 5.37, and 2.46 µM, respectively).1 |
| 别名 | BMX Inhibitor 1; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Liu, F.,Zhang, X.,Weisberg, E., et al. Discovery of a selective irreversible BMX inhibitor for prostate cancer. ACS Chemical Biology 8(7), 1423-1428 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 524.6 |
| 分子式 | C29H24N4O4S |
| CAS号 | 1431525-23-3 |
| 稳定性 | ≥ 2 years |
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