5-(N,N-dimethyl)-Amiloride (hydrochloride)
货号：
19100-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19100-1mg |
| 描述 | Sodium-hydrogen exchangers (NHE) are involved in maintaining sodium and pH balance in a variety of tissues. They are also known as sodium-hydrogen antiporters and solute carrier family 9 members. 5-(N,N-dimethyl)-Amiloride (DMA) inhibits NHE1, NHE2, and NHE3 with Ki values of 0.02, 0.25, and 14 μM, respectively.1 Because NHE1 is present in dorsal root ganglion and spinal cord, DMA was investigated for its ability to reduce inflammatory pain in rat nociception behavior tests.2 |
| 别名 | DMA;L-591,605;MK-685; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Masereel, B.,Pochet, L., and Laeckmann, D. An overview of inhibitors of Na+/H+ exchanger. Eur. J. Med. Chem. 38(6), 547-554 (2003).
2.Rocha-González, H.I.,Castadeñeda-Corral, G.,Araiza-Saldaña, C.I., et al. Identification of the Na+/H+ exchanger 1 in dorsal root ganglion and spinal cord: Its possible role in inflammatory nociception. Neuroscience 160(1), 156-164 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 294.1 |
| 分子式 | C8H12ClN7O • HCl |
| CAS号 | 2235-97-4 |
| 稳定性 | ≥ 2 years |
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