TCN 201
货号：
19086-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19086-1mg |
| 描述 | TCN 201 is a selective antagonist of NMDA receptors containing the NR2A subunit (pIC50s = 6.8 and <4.3 for human recombinant NR2A and NR2B, respectively).1 It has been shown to bind to a novel allosteric site located at the dimer interface between the GluN1 and GluN2 binding domains, thereby reducing glycine signal transduction and inhibiting NMDA receptor function.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bettini, E.,Sava, A.,Griffante, C., et al. Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors. Journal of Pharmacology and Experimental Therapeutics 335(3), 636-644 (2010).
2.Hansen, K.B.,Ogden, K.K., and Traynelis, S.F. Subunit-selective allosteric inhibition of glycine binding to NMDA receptors. Journal of Neuroscience 32(18), 6197-6208 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 461.9 |
| 分子式 | C21H17ClFN3O4S |
| CAS号 | 852918-02-6 |
| 稳定性 | ≥ 2 years |
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