PTP Inhibitor III
货号：
19059-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19059-1mg |
| 描述 | PTP Inhibitor III is an α-haloacetophenone derivative that acts as a photoreversible covalent inhibitor of protein tyrosine phosphatases (PTPs).1 It binds the catalytic domain of SHP-1 (Ki = 184 µM) and covalently reacts with free thiols, a reaction that is reversible with irradiation (350 nm). PTP Inhibitor III is cell permeable and inhibits a broad range of PTPs.2 |
| 别名 | α-Bromo-4-(carboxymethoxy)acetophenone;Protein Tyrosine Phosphatase Inhibitor III; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Arabaci, G.,Guo, X.C.,Beebe, K.D., et al. αHaloacetophenone derivatives as photoreversible covalent inhibitors of protein tyrosine phosphatases. Journal of the American Chemical Society 121(21), 5085-5086 (1999).
2.Kanda, M.,Ihara, Y.,Murata, H., et al. Glutaredoxin modulates platelet-derived growth factor-dependent cell signaling by regulating the redox status of low molecular weight protein-tyrosine phosphatase. The Journal of Biological Chemisty 281(39), 28518-28528 (2006).
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| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% |
| 计算分子量 | 273.1 |
| 分子式 | C10H9BrO4 |
| CAS号 | 29936-81-0 |
| 稳定性 | ≥ 2 years |
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