| 货号 | 18884-50mg |
| 描述 | Droperidol is a butyrophenone that acts as an antagonist at dopamine receptors (Kis = 0.25 and 0.84 nM at human D2 and D4).1 It less potently inhibits the human voltage-gated potassium channel (IC50 = 32 nM).2 Droperidol has been shown to provide relief from acute migraines and prevent nausea and vomiting in clinical trials.3,4 |
| 别名 | NSC 169874; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Seeman, P., and Tallerico, T. Antipsychotic drugs which elicit little or no parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors. Molecular Psychiatry 3(2), 123-134 (2016). 2.Rajamani, R.,Tounge, B.A.,Li, J., et al. A two-state homology model of the hERG K+ channel: Application to ligand binding. Bioorganic & Medicinal Chemistry Letters 15(6), 1737-1741 (2005). 3.Saguil, A., and Lax, J.W. Acute migraine treatment in emergency settings. American Family Physician 89(9), 742-744 (2014). 4.Griffiths, J.D.,Gyte, G.M.L.,Paranjothy, S., et al. Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section. Cochrane Database Syst.Rev. 9, 1-224 (2012). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 379.4 |
| 分子式 | C22H22FN3O2 |
| CAS号 | 548-73-2 |
| 稳定性 | ≥ 2 years |
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