Triclabendazole
货号：
18883-100mg 基本售价：
350.0 元 规格：
100 mg
产品信息
概述| 货号 | 18883-100mg |
| 描述 | Triclabendazole is a member of the benzimidazole family of anthelmintics. It is effective against F. hepatica helminths that cause fascioliasis, reducing secreted protease enzyme activities that are critical for the invasion, migration, nutrition, and survival of the parasite.1 In yeast and mammalian cells, triclabendazole was shown to inhibit adenylyl cyclase in the Ras-adenylyl cyclase-protein kinase A nutrient-sensing pathway and to prevent apoptosis induced by the Parkinson’s disease-related protein α-synuclein, demonstrating a protective role during various cellular stresses.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Shrifi, Y.,Farahnak, A.,Golestani, A., et al. Triclabendazole effect on protease enzyme activity in the excretory- secretory products of Fasciola hepatica in vitro. Iran.J.parasitol. 9(1), 107-113 (2014).
2.Lee, Y.J.,Shi, R., and Witt, S.N. The small molecule triclabendazole decreases the intracellular level of cyclic AMP and increases resistance to stress in Saccharomyces cerevisiae. PLoS One 8(5), (2013).
3.Lee, Y.J.,Burlet, E.,Wang, S., et al. Triclabendazole protects yeast and mammalian cells from oxidative stress: Identification of a potential neuroprotective compound. Biochemical and Biophysical Research Communications 414(1), 205-208 (2011).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 359.7 |
| 分子式 | C14H9Cl3N2OS |
| CAS号 | 68786-66-3 |
| 稳定性 | ≥ 2 years |
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