ML-264
货号：
18880-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 18880-1mg |
| 描述 | ML-264 is a selective inhibitor of Krüppel-like factor 5 (KLF5), a zinc finger-containing transcription factor that is highly expressed in rapidly dividing intestinal epithelial cells. It displays an IC50 value of 29 nM in a cell-based assay for proliferation of KLF5-expressing DLD-1 cells and an IC50 value of 81 nM in a cell-based luciferase assay but does not inhibit kinases associated with the KLF5 pathway, as determined using a panel of 47 selected kinases.1 ML-264 induces death in most colon cancer cell lines (HCT116, IC50 = 560 nM; HT-29, IC50 = 130 nM; SW620, IC50 = 430 nM), with cytotoxicity toward an established xenograft mouse model of colon cancer as well.1,2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bialkowska, A.,Crisp, M.,Maddoux, F., et al. ML264: An antitumor agent that potently and selectively inhibits krüppel-like factor five (KLF5) expression: A probe for studying colon cancer development and progression. Probe Reports from the NIH Molecular Libraries Program (2011).
2.de Sabando, A.R.,Wang, C.,He, Y., et al. ML264, a novel small-molecule compound that potently inhibits growth of colorectal cancer. Mol. Cancer Ther. 15(1), 72-83 (2016).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 384.9 |
| 分子式 | C17H21ClN2O4S |
| CAS号 | 1550008-55-3 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
