AC-5216
货号：
18522-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 18522-1mg |
| 描述 | AC-5216 is a high affinity agonist of the 18 kDa translocator protein (TSPO, previously called the peripheral benzodiazepine receptor) that exhibits a Ki value of 0.297 nM in rat whole brain and IC50 values of 2.73 and 3.04 nM, respectively, against human and rat glial TSPO.1 AC-5216 produces anxiolytic and antidepressant effects in various animal models, without inducing benzodiazepine-like adverse effects.1,2 |
| 别名 | Emapunil;XBD-173; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kita, A.,Kohayakawa, H.,Kinoshita, T., et al. Antianxiety and antidepressant-like effects of AC-5216, a novel mitochondrial benzodiazepine receptor ligand. Brit.J.Pharmacol. 142, 1059-1072 (2004).
2.Qiu, Z.K.,Zhang, L.M.,Zhao, N., et al. Repeated administration of AC-5216, a ligand for the 18 kDa translocator protein, improves behavioral deficits in a mouse model of post-traumatic stress disorder. Prog.Neuropsychopharmacol.Biol.Psychiatry 45, 40-46 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 401.5 |
| 分子式 | C23H23N5O2 |
| CAS号 | 226954-04-7 |
| 稳定性 | ≥ 2 years |
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