| 货号 | 18496-1mg |
| 描述 | Cdc42 is a member of the Rho GTPase subfamily that has roles in cytoskeleton organization, cell cycle progression, signal transduction, and vesicle trafficking. It cycles between a GTP-bound active state and a GDP-bound inactive state. ML 141 is a noncompetitive, allosteric inhibitor of Cdc42 (EC50 = 2.1 µM) with no inhibitory action against Rho, Ras, Rab, or Rac.1,2 It also inhibits the constitutively active Cdc42 Q61L mutant (EC50 = 2.6 µM).1 ML 141 blocks Cdc42-dependent filopodia formation in 3T3 cells and migration of ovarian cancer cells, prevents Cdc42-regulated virus infection, and inhibits the signaling pathway of VLA-4 integrin.1 It is a useful tool to interrogate the role of Cdc42 intracellular signaling and cell activity.3,4 |
| 别名 | CID2950007; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hong, L.,Kenney, S.R.,Phillips, G.K., et al. Characterization of a Cdc42 protein inhibitor and its use as a molecular probe. The Journal of Biological Chemisty 288(12), 8531-8543 (2013). 2.Surviladze, Z.,Waller, A.,Strouse, J.J., et al. A potent and selective inhibitor of Cdc42 GTPase. (2010). 3.Kalwat, M.A.,Yoder, S.M.,Wang, Z., et al. A p21-activated kinase (PAK1) signaling cascade coordinately regulates F-actin remodeling and insulin granule exocytosis in pancreatic β cells. Biochemical Pharmacology 85(6), 808-816 (2013). 4.Pinzaglia, M.,Montaldo, C.,Polinari, D., et al. EIF6 over-expression increases the motility and invasiveness of cancer cells by modulating the expression of a critical subset of membrane-bound proteins. BMC Cancer 15, 131-146 (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 407.5 |
| 分子式 | C22H21N3O3S |
| CAS号 | 71203-35-5 |
| 稳定性 | ≥ 2 years |
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