TCS 1102
货号：
18495-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 18495-1mg |
| 描述 | Orexin receptors 1 (OX1R) and OX2R mediate the action of the neuropeptides orexin A and orexin B. TCS 1102 is a dual antagonist of both OX1R and OX2R (Kis = 0.2 and 3 nM, respectively).1 It is a poor substrate for P-glycoprotein and, as a result, demonstrates good brain penetration when administered intraperitoneally.1 Dual orexin receptor antagonists, including TCS 1102, promote sleep and prevent drug-induced plasticity and drug relapse.2 Systemic injection of TCS 1102 (10 mg/kg i.p.) in rats decreases fear and anxiety in response to acute episodes of stress.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bergman, J.M.,Roecker, A.J.,Mercer, S.P., et al. Proline bis-amides as potent dual orexin receptor antagonists. Bioorganic & Medicinal Chemistry Letters 18(4), 1425-1430 (2008).
2.Winrow, C.J.,Tanis, K.Q.,Reiss, D.R., et al. Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure. Neuropharmacology 58(1), 185-194 (2010).
3.Chen, X.,Wang, H.,Lin, Z., et al. Orexins (hypocretins) contribute to fear and avoidance in rats exposed to a single episode of footshocks. Brain Struct.Funct. 219(6), 2103-2118 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 470.6 |
| 分子式 | C27H26N4O2S |
| CAS号 | 916141-36-1 |
| 稳定性 | ≥ 2 years |
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