ME0328
货号：
18488-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 18488-1mg |
| 描述 | The poly(ADP-ribose) polymerases (PARPs) are enzymes with roles in DNA repair, apoptosis, inflammation, and other cellular events, particularly in response to reactive oxygen and nitrogen species.1,2 ME0328 is an inhibitor of PARP3 (IC50 = 0.89 µM), which is a regulator of DNA repair and mitotic progression.3 It displays selectivity for PARP3 over 12 other PARP family members. ME0328 is cell permeable and elicits PARP3-specific effects at submicromolar concentrations.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Davar, D.,Beumer, J.H.,Hamieh, L., et al. Role of PARP inhibitors in cancer biology and therapy. Current Medicinal Chemistry 19(23), 3907-3921 (2012).
2.Mathews, M.T., and Berk, B.C. PARP-1 inhibition prevents oxidative and nitrosative stress-induced endothelial cell death via transactivation of the VEGF receptor 2. Arteriosclerosis, Thrombosis, and Vascular Biology 28, 711-717 (2008).
3.Lindgren, A.E.,Karlberg, T.,Thorsell, A.G., et al. PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3. ACS Chem Biol. 8(8), 1698-1703 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 321.4 |
| 分子式 | C19H19N3O2 |
| CAS号 | 1445251-22-8 |
| 稳定性 | ≥ 2 years |
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