| 货号 | 18474-50mg |
| 描述 | TMPyP4 is a cationic porphyrin that intercalates into and stabilizes G-quadruplexes, which are formed by DNA and RNA sequences composed of blocks of guanine residues.1 In this way, TMPyP4 inhibits telomerase activity (IC50 ≤ 50 µM), blocking the clonogenic growth and migration of cancer cells in culture and in vivo.2,3,4 TMPyP4 also inhibits acetylcholinesterase at doses of 0.1 to 1.0 mM.5 |
| 别名 | TMP-1363;TMPyP4 4-methylbenzenesulfonate; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Fiel, R.J.,Howard, J.C.,Mark, E.H., et al. Interaction of DNA with a porphyrin ligand: Evidence for intercalation. Nucleic Acids Research 6(9), 3093-3118 (1979). 2.Izbicka, E.,Wheelhouse, R.T.,Raymond, E., et al. Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells. Cancer Research 59, 639-644 (1999). 3.Rapozzi, V.,Zorzet, S.,Zacchigna, M., et al. Anticancer activity of cationic porphyrins in melanoma tumour-bearing mice and mechanistic in vitro studies. Molecular Cancer 13, 75 (2014). 4.Rha, S.Y.,Izbicka, E.,Lawrence, R., et al. Effect of telomere and telomerase interactive agents on human tumor and normal cell lines. Clinical Cancer Research 6, 987-993 (2000). 5.Fujiwara, N.,Mazzola, M.,Cai, E., et al. TMPyP4, a stabilizer of nucleic acid secondary structure, is a novel acetylcholinesterase inhibitor. PLoS One 10(9), e0139167 (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 1363.6 |
| 分子式 | C44H38N8 • 4C7H7O3S |
| CAS号 | 36951-72-1 |
| 稳定性 | ≥ 2 years |
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