CIQ
货号：
17997-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17997-1mg |
| 描述 | CIQ is a substituted tetrahydroisoquinoline that acts as a subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors.1 It is without effect at subunits NR2A, NR2B, or glutamate receptors. CIQ enhances receptor responses two-fold (EC50 = 3 µM) by increasing channel opening frequency for glutamate or glycine.1 It is a positive allosteric modulator that does not alter agonist EC50values.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mullasseril, P.,Hansen, K.B.,Vance, K.M., et al. A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors. Nat. Commun. 1:90, (2010).
2.Monaghan, D.T.,Irvine, M.W.,Costa, B.M., et al. Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators. Neurochem Int. 61(4), 581-592 (2012).
3.Hackos, D.H., and Hanson, J.E. Diverse modes of NMDA receptor positive allosteric modulation: Mechanisms and consequences. Neuropharmacology 112(Pt A), 34-45 (2017).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 467.9 |
| 分子式 | C26H26ClNO5 |
| CAS号 | 486427-17-2 |
| 稳定性 | ≥ 2 years |
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