Nitisinone
货号：
17924-50mg 基本售价：
350.0 元 规格：
50 mg
产品信息
概述| 货号 | 17924-50mg |
| 描述 | Nitisinone is a reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase, an enzyme involved in the catabolism of tyrosine in mammals and the biosynthesis of plastoquinone in plants.1 This compound has been evaluated as a herbicide, while also used in the treatment of hereditary tyrosinemia type 1, alkaptonuria, and oculocutaneous albinism, all of which involve a disorder in tyrosine metabolism.1,2,3 |
| 别名 | NTBC;SC-0735; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hall, M.G.,Wilks, M.F.,McLean Provan, W., et al. Pharmacokinetics and pharmacodynamics of NTBC (2-(2-nitro-4-fluoromethylbenzoyl)-1,3-cyclohexanedione) and mesotrione, inhibitors of 4-hydroxyphenyl pyruvate dioxygenase (HPPD) following a single dose to healthy male volunteers. British Journal of Clinical Pharmacology 52(2), 167-177 (2001).
2.Cox, T.M. Alkaptonuria: Leading to the treasure in exceptions. JIMD Rep. 5, 57-49 (2012).
3.Onojafe, I.F.,Adams, D.R.,Simeonov, D.R., et al. Nitisinone improves eye and skin pigmentation defects in a mouse model of oculocutaneous albinism. Journal of Clinical Investigation 121(10), 3914-3923 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 329.2 |
| 分子式 | C14H10F3NO5 |
| CAS号 | 104206-65-7 |
| 稳定性 | ≥ 2 years |
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