BI-9564
货号：
17897-500ug 基本售价：
350.0 元 规格：
500 ug
产品信息
概述| 货号 | 17897-500ug |
| 描述 | BI-9564 is a selective inhibitor of BRD9 and BRD7 bromodomains (Kds = 14.1 and 239 nM; IC50s = 75 nM and 3.4 µM, respectively) that demonstrates cellular activity by semi-quantitative FRAP assay with ~90% inhibition of BRD9 and BRD7 at 0.1 µM and 1 µM, respectively.1,2 It does not bind to other bromodomain-containing BET family members (IC50s >100 µM as assessed by AlphaScreen), kinases, or G protein-coupled receptors and shows off-target selectivity only to the CECR2 bromodomain in in vitro ITC assays (Kd = 258 nM), but not in cell-based assays at concentrations up to 1 µM.1 BI-9564 has been shown to inhibit the growth of EOL-1 AML cells both in vitro(EC50 = 800 nM) and in a disseminated mouse model of AML (180 mg/kg/day).1 See the Structural Genomics Consortium (SGC) website for more information. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Martin, L.J.,Koegl, M.,Bader, G., et al. Structure-based design of an in vivo active selective BRD9 inhibitor. Journal of Medicinal Chemistry 59(10), 4462-4475 (2016).
2.Karim, R.M., and Schönbrunn, E. An advanced tool to interrogate BRD9. Journal of Medicinal Chemistry (2016).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 353.4 |
| 分子式 | C20H23N3O3 |
| CAS号 | 1883429-22-8 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
