| 货号 | 17587-1mg |
| 描述 | Ataxia-telangiectasia and Rad3-related protein (ATR) is a serine/threonine kinase that activates DNA processes related to the DNA damage response. VE-821 is an ATP-competitive inhibitor of ATR (IC50 = 26 nM).1,2 It augments DNA damage and cell death of cancer cells in response to radiation under normal and hypoxic conditions.2,3,4 VE-821 also sensitizes cancer cells to chemotherapy.3,5,6 |
| 别名 | ATR Inhibitor IV; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Reaper, P.M.,Griffiths, M.R.,Long, J.M., et al. Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR. Nature Chemical Biology 7(7), 428-430 (2011). 2.Pires, I.M.,Olcina, M.M.,Anbalagan, S., et al. Targeting radiation-resistant hypoxic tumour cells through ATR inhibition. British Journal of Cancer 107, 291-299 (2012). 3.Prevo, R.,Fokas, E.,Reaper, P.M., et al. The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy. Cancer Biology and Therapy 13(11), 1072-1081 (2012). 4.Salovská, B.,Fabrik, I.,Durisová, K., et al. Radiosensitization of human leukemic HL-60 cells by ATR kinase inhibitor (VE-821): Phosphoproteomic analysis. International Journal of Molecular Sciences 15, 12007-12026 (2014). 5.Huntoon, C.J.,Flatten, K.S.,Wahner Hendrickson, A.E., et al. ATR inhibition broadly sensitizes ovarian cancer cells to chemotherapy independent of BRCA status. Cancer Research 73(12), 3683-3691 (2013). 6.Flynn, R.L.,Cox, K.E.,Jeitany, M., et al. Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors. Science 347(6219), 273-277 (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 368.4 |
| 分子式 | C18H16N4O3S |
| CAS号 | 1232410-49-9 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |