| 货号 | 17565-1g |
| 描述 | Zoxazolamine is a potent skeletal muscle relaxant that also has uricosuric activity.1 It is metabolized by an array of cytochrome P450 (CYP450) isoforms. As a result, recovery time from zoxazolamine-induced paralysis is used as a measure for change in CYP450 expression in mice.2,3 Zoxazolamine also dose-dependently modulates the expression of pigmentation factors in a keratinocyte-melanocyte co-culture system.4 |
| 别名 | 2-Amino-5-chlorobenzoxazole;Contrazole;NSC 24995; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Montgomery, D.B., and Ogryzlo, M.A. Comparison of the uricosuric effect of sulfinpyrazone (anturan) and zoxazolamine (flexin). Can.Med.Assoc.J. 83, 885-888 (1960). 2.Hernandez, J.P.,Mota, L.C.,Huang, W., et al. Sexually dimorphic regulation and induction of P450s by the constitutive androstane receptor (CAR). Toxicology 256(1-2), 53-64 (2009). 3.Chen, W.D.,Fu, X.,Dong, B., et al. Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liver. Hepatology 56(4), 1499-1509 (2012). 4.Lee, J.H.,Chen, H.,Kolev, V., et al. High-throughput, high-content screening for novel pigmentation regulators using a keratinocyte/melanocyte co-culture system. Experimental Dermatology 23(2), 125-129 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 168.6 |
| 分子式 | C7H5ClN2O |
| CAS号 | 61-80-3 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |