Chk2 Inhibitor II
货号：
17552-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17552-1mg |
| 描述 | Chk2 inhibitor II is a selective, ATP-competitive inhibitor of the DNA damage control kinase, checkpoint kinase 2 (IC50 = 15 nM).1 It has been shown to prevent apoptosis in human T-cells exposed to ionizing radiation (EC50 = 3-7.6 µM).1 This compound has been used to target the role of Chk2 in cellular signaling in response to DNA damage.2 |
| 别名 | BML-277;C 3742;Checkpoint Kinase 2 Inhibitor II; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Arienti, K.L.,Brunmark, A.,Axe, F.U., et al. Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles. Journal of Medicinal Chemistry 48(6), 1873-1885 (2005).
2.Pereg, Y.,Lam, S.,Teunisse, A., et al. Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage. Molecular and Cellular Biology 26(18), 6819-6831 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 363.8 |
| 分子式 | C20H14ClN3O2 |
| CAS号 | 516480-79-8 |
| 稳定性 | ≥ 2 years |
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