DMPQ (hydrochloride)
货号：
17551-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17551-1mg |
| 描述 | DMPQ is a potent inhibitor of human platelet-derived growth factor receptor β (PDGFRβ, IC50 = 80 nM).1 It displays greater than 100-fold selectivity for PDGFRβ over other tyrosine and serine/threonine kinases.1 DMPQ effectively blocks the PDGF-mediated increase in the protein, Survival Motor Neuron, in fibroblasts from patients with spinal muscular atrophy.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Dolle, R.E.,Dunn, J.A.,Bobko, M., et al. 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular β-type platelet-derived growth factor receptor tyrosine kinase. Journal of Medicinal Chemistry 37, 2627-2629 (1994).
2.Makhortova, N.R.,Hayhurst, M.,Cerqueira, A., et al. A screen for regulators of survival of motor neuron protein levels. Nature Chemical Biology 7(8), 544-552 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 339.2 |
| 分子式 | C16H14N2O2 • 2HCl |
| CAS号 | 1123491-15-5 |
| 稳定性 | ≥ 2 years |
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