| 货号 | 17549-10mg |
| 描述 | Nitrendipine is a dihydropyridine used as an antihypertensive agent due to its ability to block L-type and T-type calcium channels, which play key roles in excitation-contraction coupling in cardiac and vascular smooth muscle cells, producing vasodilatory actions.1,2,3,4 It also binds to adenosine A1, A2A, and A3 receptors with Ki values of 8.96, 23.0, and 8.3 µM, respectively.5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Furukawa, T.,Yamakawa, T.,Midera, T., et al. Selectivities of dihydropyridine derivatives in blocking Ca2+ channel subtypes expressed in Xenopus oocytes. J. Pharmacol. Exp. Ther. 291(2), 464-473 (1999). 2.Triggle, D.J., and Rampe, D. 1,4-Dihydropyridine activators and antagonists: Structural and functional distinctions. Trends in Pharamacological Sciences 10(12), 507-511 (1989). 3.Perez-Reyes, E.,Van Deusen, A.L., and Vitko, I. Molecular pharmacology of human Cav3.2 T-type Ca2+ channels: Block by antihypertensives, antiarrhythmics, and their analogs. Journal of Pharmacology and Experimental Therapeutics 328(2), 621-627 (2009). 4.Sonoda, S., and Ochi, R. Independent modulation of L-type Ca2+ channel in guinea pig ventricular cells by nitrendipine and isoproterenol. Jpn.HeartJ. 42(6), 771-780 (2001). 5.van Rhee, A.M.,Jiang, J.L.,Melman, N., et al. Interaction of 1,4-dihydropyridine and pyridine derivatives with adenosine receptors: Selectivity for A3 receptors. Journal of Medicinal Chemistry 39(15), 2980-2989 (1996). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 360.4 |
| 分子式 | C18H20N2O6 |
| CAS号 | 39562-70-4 |
| 稳定性 | ≥ 2 years |
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