GTP 14564
货号：
17543-500ug 基本售价：
350.0 元 规格：
500 ug
产品信息
概述| 货号 | 17543-500ug |
| 描述 | GTP 14564 is an inhibitor of class III receptor tyrosine kinases (IC50s = 0.3 µM for c-Fms, c-Kit, ITD-FLT3 and 1 µM for PDGFRβ).1 It is without effect against a panel of non-receptor tyrosine and serine/threonine kinases.1 GTP 14564 blocks the proliferation of leukemia cells stimulated with FLT3 ligand by preventing the activation of STAT5.1,2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Murata, K.,Kumagai, H.,Kawashima, T., et al. Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3). J.Bio.Chem. 278(35), 32892-32898 (2003).
2.Yao, Q.,Nishiuchi, R.,Kitamura, T., et al. Human leukemias with mutated FLT3 kinase are synergistically sensitive to FLT3 and Hsp90 inhibitors: The key role of the STAT5 signal transduction pathway. Leukemia 19(9), 1605-1612 (2005).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 234.3 |
| 分子式 | C15H10N2O |
| CAS号 | 34823-86-4 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
