IRAK-1/4 Inhibitor
货号：
17540-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17540-1mg |
| 描述 | Interleukin-1 receptor-associated kinases (IRAKs) are important mediators in the signal transduction of Toll/IL-1 receptor (TIR) family members. Dysregulation of TIR signaling, typified by increased NF-κB activity, results in the development of some cancers and other diseases, making the development of IRAK inhibitors a potential therapeutic strategy. IRAK-1/4 inhibitor is a benzimidazole that disrupts the activity of IRAK-1 and -4 with IC50 values of 0.3 and 0.2 µM, respectively.1 It demonstrates IC50 values >10 µM in a panel of 27 other kinases tested.1 This compound has been used to inhibit a pro-inflammatory response in microglia isolated from clinically diagnosed Alzheimer’s disease patients.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Powers, J.P.,Li, S.,Jaen, J.C., et al. Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4. Bioorganic & Medicinal Chemistry Letters 16(11), 2842-2845 (2006).
2.Hoozemans, J.J.M.,van Haastert, E.S.,Mulder, S.D., et al. Increased IRAK-4 kinase activity in Alzheimer’s disease; IRAK-¼ inhibitor I prevents pro-inflammatory cytokine secretion but not the uptake of amyloidβby primary human glia. J.Clin.Cell.Immunol. 5, (2014).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 395.4 |
| 分子式 | C20H21N5O4 |
| CAS号 | 509093-47-4 |
| 稳定性 | ≥ 2 years |
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