| 货号 | 17537-1g |
| 描述 | Nicardipine is a dihydropyridine L-type calcium channel antagonist that displays antihypertensive and antianginal activity.1 It is reported to inhibit adenosine A1, A2A, and A3 receptors with Ki values of 19.6, 63.8, and 3.25 µM, respectively, and can inhibit cytochrome P450 3A4 catalytic activity with an IC50 value of 0.148 µM.2,3 Additionally, nicardipine has been shown to activate transient receptor potential A1 channels, producing an increase in Ca2+(EC50 = 0.5 µM).4 |
| 别名 | RS 69216; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Triggle, D.J., and Rampe, D. 1,4-Dihydropyridine activators and antagonists: Structural and functional distinctions. Trends in Pharamacological Sciences 10(12), 507-511 (1989). 2.van Rhee, A.M.,Jiang, J.L.,Melman, N., et al. Interaction of 1,4-dihydropyridine and pyridine derivatives with adenosine receptors: Selectivity for A3 receptors. Journal of Medicinal Chemistry 39(15), 2980-2989 (1996). 3.Stresser, D.M.,Blanchard, A.P.,Turner, S.D., et al. Substrate-dependent modulation of CYP3A4 catalytic activity: Analysis of 27 test compounds with four fluorometric substrates. Drug Metabolism and Disposition 28(12), 1440-1448 (2000). 4.Baraldi, P.G.,Preti, D.,Materazzi, S., et al. Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents. J. Med. Chem. 53(14), 5085-5107 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 516 |
| 分子式 | C26H29N3O6 • HCl |
| CAS号 | 54527-84-3 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |