| 货号 | 17501-1mg |
| 描述 | Cytosporone B is a naturally occurring agonist for the nuclear receptor Nur77 (IC50 = 0.278 nM).1 Activation of Nur77 with cytosporone B induces the expression of Nur77-dependent genes, including the gene for Nur77 itself.1 Signaling through Nur77 induces apoptosis in cancer cells and retards xenograft tumor growth.1 It also induces genes related to gluconeogenesis and decreases atherosclerosis progression in mice fed a high fat and high cholesterol diet.1,2 Cytosporone B is brain penetrant and aggravates early brain injury in rats when given (13 mg/kg intraperitoneally) after experimentally-induced subarachnoid hemorrhage.3 Cytosporone B also has antibacterial properties.4,5 |
| 别名 | Csn-B;Dothiorelone G; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Zhan, Y.,Du, X.,Chen, H., et al. Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nature Chemical Biology 4, 548-556 (2008). 2.Hu, Y.W.,Zhang, P.,Yang, J.Y., et al. Nur77 decreases atherosclerosis progression in apoE-/- mice fed a high-fat/high-cholesterol diet. PLoS One 9(1), 1-12 (2014). 3.Dai, Y.,Zhang, W.,Sun, Q., et al. Nuclear receptor nur77 promotes cerebral cell apoptosis and induces early brain injury after experimental subarachnoid hemorrhage in rats. Journal of Neuroscience Research 92, 1110-1121 (2015). 4.Beau, J.,Mahid, N.,Burda, W.N., et al. Epigenetic tailoring for the production of anti-infective cytosporones from the marine fungus Leucostoma persoonii. Mar.Drugs 10(4), 762-774 (2012). 5.Li, J.,Lv, C.,Sun, W., et al. Cytosporone B, an inhibitor of the type III secretion system of Salmonella enterica serovar Typhimurium. Antimicrobial Agents and Chemotherapy 57(5), 2191-2198 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 322.4 |
| 分子式 | C18H26O5 |
| CAS号 | 321661-62-5 |
| 稳定性 | ≥ 2 years |
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