| 货号 | 17402-5g |
| 描述 | Chrysin is a natural flavonoid with antioxidant, anti-inflammatory, and anticancer properties. It blocks COX-2 gene expression, PGE2 production, and hydroxyl radical formation in LPS-induced RAW 264.7 cells.1,2 Chrysin inhibits insulin-induced HIF-1α expression (~50% at 10 µM) in human prostate cancer DU145 cells and blocks DU145 xenograft-induced angiogenesis in vivo.3 In a mouse model of ischemia/reperfusion injury, chrysin decreased pro-inflammatory gene expression and oxidative stress, resulting in a reduction of infarct volume and neurological defects.4 |
| 别名 | 5,7-Dihydroxyflavone;NSC 407436; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Woo, K.J.,Jeong, Y.J.,Inoue, H., et al. Chrysin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression through the inhibition of nuclear factor for IL-6 (NF-IL6) DNA-binding activity. FEBS Letters 579(3), 705-711 (2005). 2.Harris, G.K.,Qian, Y.,Leonard, S.S., et al. Luteolin and chrysin differentially inhibit cyclooxygenase-2 expression and scavenge reactive oxygen species but similarly inhibit prostaglandin-E2 formation in RAW 264.7 cells. Journal of Nutrition 136(6), 1517-1521 (2006). 3.Fu, B.,Xue, J.,Li, Z., et al. Chrysin inhibits expression of hypoxia-inducible factor-1α through reducing hypoxia-inducible factor-1α stability and inhibiting its protein synthesis. Molecular Cancer Therapeutics 6(1), 220-226 (2007). 4.Yao, Y.,Chen, L.,Xiao, J., et al. Chrysin protects against focal cerebral ischemia/reperfusion injury in mice through attenuation of oxidative stress and inflammation. International Journal of Molecular Sciences 15(11), 20913-20926 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 254.2 |
| 分子式 | C15H10O4 |
| CAS号 | 480-40-0 |
| 稳定性 | ≥ 2 years |
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