| 货号 | 16886-1mg |
| 描述 | NNGH is a cell-permeable, broad-spectrum inhibitor of matrix metalloproteinases (MMPs). It blocks the activity of MMP-8, -9, -12, -13, and -20 with Ki values of 9, 2.6, 4.3, 3.1, and 17 nM, respectively.1,2 It also inhibits MMP-1, -3, -7, and -10 with Ki values of 0.17, 0.13, 13, and 0.1 µM, respectively.1,2 It is commonly used to study the role of MMP-3 (stromelysin 1) in biological systems.3,4,5 |
| 别名 | N-Isobutyl-N-(4-methoxyphenylsulfonyl)glycyl Hydroxamic Acid;Matrix Metalloproteinase-3 Inhibitor II;MMP-3 Inhibitor II; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Arendt, Y.,Banci, L.,Bertini, I., et al. Catalytic domain of MMP20 (Enamelysin) - the NMR structure of a new matrix metalloproteinase. FEBS Letters 581, 4723-4726 (2007). 2.Attolino, E.,Calderone, V.,Dragoni, E., et al. Structure-based approach to nanomolar, water soluble matrix metalloproteinases inhibitors (MMPIs). European Journal of Medicinal Chemistry (2010). 3.Kim, Y.S.,Kim, S.S.,Cho, J.J., et al. Matrix metalloproteinase-3: A novel signaling proteinase from apoptotic neuronal cells that activates microglia. Journal of Neuroscience 25(14), 3701-3711 (2005). 4.Woo, M.S.,Park, J.S.,Choi, I.Y., et al. Inhibition of MMP-3 or -9 suppresses lipopolysaccharide-induced expression of proinflammatory cytokines and iNOS in microglia. Journal of Neurochemistry 106, 770-780 (2008). 5.Christianson, C.A.,Fitzsimmons, B.L.,Shim, J.H., et al. Spinal matrix metalloproteinase 3 mediates inflammatory hyperalgesia via a TNF dependent mechanism. Neuroscience 200, 199-210 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥99% |
| 计算分子量 | 316.4 |
| 分子式 | C13H20N2O5S |
| CAS号 | 161314-17-6 |
| 稳定性 | ≥ 1 year |
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