AT7867
货号：
16848-500ug 基本售价：
350.0 元 规格：
500 ug
产品信息
概述| 货号 | 16848-500ug |
| 描述 | AT7867 is a potent and orally bioavailable inhibitor of Akt isoforms Akt1, 2, and 3 (IC50s = 32, 17, and 47 nM, respectively).1 It also inhibits p70S6 kinase and PKA (IC50s = 85 and 20 nM, respectively), but is without effect against a panel of other kinases.1 AT7867 inhibits growth and induces apoptosis in a variety of cancer cell lines in vitro and suppresses tumor growth of PTEN-deficient xenografts in mice.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Grimshaw, K.M.,Hunter, L.-J.K.,Yap, T.A., et al. AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growth. Mol. Cancer Ther. 9(5), 1100-1110 (2010).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 337.9 |
| 分子式 | C20H20ClN3 |
| CAS号 | 857531-00-1 |
| 稳定性 | ≥ 2 years |
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