AT7519 (hydrochloride)
货号：
16231-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 16231-1mg |
| 描述 | AT7519 is an ATP-competitive inhibitor of cyclin-dependent kinases (Cdks) with IC50 values of 210, 47, 100, 13, 170, and <10 nM for Cdk1, 2, 4, 5, 6, and 9, respectively.1 It is less potent against Cdk3 and Cdk7 and inactive against non-Cdk kinases save for GSK3β (IC50 = 89 nM).1 AT7519 demonstrates antiproliferative activity against a wide variety of human tumor cell lines (IC50s = 40-940 nM in vitro), inhibiting cell cycle progression and inducing apoptosis, and prevents tumor growth in human tumor xenograft models.1,2 AT7519 induces activation of GSK3β by down-regulating GSK3β phosphorylation, which contributes to AT7519-induced apoptosis.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Squires, M.S.,Feltell, R.E.,Wallis, N.G., et al. Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines. Molecular Cancer Therapeutics 8(2), 324-332 (2009).
2.Santo, L.,Vallet, S.,Hideshima, T., et al. AT7519, a novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-βactivation and RNA polymerase II inhibition. Oncogene 29(16), 2325-2336 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 418.7 |
| 分子式 | C16H17Cl2N5O2 • HCl |
| CAS号 | 902135-91-5 |
| 稳定性 | ≥ 2 years |
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