| 货号 | 16216-500mg |
| 描述 | Juglone is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. It has allelopathic actions, suppressing growth, photosynthesis, and respiration in plants and other organisms, although some bacteria can metabolize juglone.1,2 Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family, including human Pin1, yeast Ess1/Ptf1, and E. coli parvulin (Ki = 55.9 nM).3 Juglone also blocks transcription by RNA polymerases I, II, and III (IC50s = 2-7 µM) and attenuates kidney fibrosis in rats treated with unilateral ureteral obstruction, both through Pin1-independent mechanisms.4,5 |
| 别名 | 5-Hydroxy-1,4-naphthoquinone;NSC 34266;NSC 153189;NSC 622948; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hejl, A.A.,Einhellig, F.A. and Rasmussen, J.A. Effects of juglone on growth, photosynthesis, and respiration. Journal of Chemical Ecology 19(3), 559-568 (1993). 2.Williamson, G.B. and Weidenhamer, J.D. Bacterial degradation of juglone: Evidence against allelopathy? Journal of Chemical Ecology 16(5), 1739-1742 (1990). 3.Hennig, L.,Christner, C.,Kipping, M., et al. Selective inactivation of parvulin-like peptidyl-prolyl cis/trans isomerases by juglone. Biochemistry 37(17), 5953-5960 (1998). 4.Chao, S.H.,Greenlead, A.L. and Price, D.H. Juglone, an inhibitor of the peptidyl-prolyl isomerase Pin1, also directly blocks transcription. Nucleic Acids Research 29(3), 767-773 (2001). 5.Reese, S.,Vidyasagar, A.,Jacobson, L., et al. The Pin 1 inhibitor juglone attenuates kidney fibrogenesis via Pin 1-independent mechanisms in the unilateral ureteral occlusion model. Fibrogenesis Tissue Repair 3, 1 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 174.2 |
| 分子式 | C10H6O3 |
| CAS号 | 481-39-0 |
| 稳定性 | ≥ 2 years |
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