XCT790
货号：
16035-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 16035-1mg |
| 描述 | XCT790 is an inverse agonist of estrogen-related receptor α (ERRα; IC50 = ~300-500 nM).1,2 It demonstrates 90-100% inhibition of ERRα constitutive activity and has no significant activity at related nuclear receptors at 10 µM.2 XCT790 associates with the ligand-binding domain of ERRα and blocks ERRα/PGC-1α-dependent signaling, suppressing the expression of monoamine oxidases A and B.2 XCT790 induces proteasomal degradation of ERRα and potentiates the degradation of the estrogen receptor ERα by fulvestrant (Item No. 10011269).3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Busch, B.B.,Stevens, W.C., Jr.,Martin, R., et al. Identification of a selective inverse agonist for the orphan nuclear receptor estrogen-related receptor α. Journal of Medicinal Chemistry 47(23), 5593-5596 (2004).
2.Willy, P.J.,Murray, I.R.,Qlan, J., et al. Regulation of PPARγ coactivator 1α (PGC-1α) signaling by an estrogen-related receptor α (ERRα) ligand. Proceedings of the National Academy of Sciences of the United States of America 101(24), 8912-8917 (2004).
3.Lanvin, O.,Bianco, S.,Kersual, N., et al. Potentiation of ICI182,780 (Fulvestrant)-induced estrogen receptor-α degradation by the estrogen receptor-related receptor-α inverse agonist XCT790. The Journal of Biological Chemisty 282(39), 28328-28334 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 596.4 |
| 分子式 | C23H13F9N4O3S |
| CAS号 | 725247-18-7 |
| 稳定性 | ≥ 2 years |
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