| 货号 | 15492-25mg |
| 描述 | Zidovudine is a nucleoside reverse transcriptase inhibitor that, following triphosphorylation by thymidine kinase, potently blocks replication of HIV (EC50 = 3 nM) with low cytotoxicity (CC50 > 5 μM).1,2,3,4 It is commonly used in combination therapy to slow the replication of HIV in vivo.5 |
| 别名 | Azidothymidine;AZT;NSC 602670;Retrovir;ZDV; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Mitsuya, H.,Weinhold, K.J.,Furman, P.A., et al. 3-Azido-3-deoxythymidine (BW A509U): An antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro. Proceedings of the National Academy of Sciences of the United States of America 82(20), 7096-7100 (1985). 2.Palomino, E.,Meltsner, B.R.,Kessel, D., et al. Synthesis and in vitro evaluation of some modified 4-thiopyrimidine nucleosides for prevention or reversal of AIDS-associated neurological disorders. Journal of Medicinal Chemistry 33(1), 258-263 (1990). 3.Adams, D.R.,Perez, C.,Maillard, M., et al. Preparation and anti-HIV activity of N-3-substituted thymidine nucleoside analogs. Journal of Medicinal Chemistry 40(10), 1550-1558 (1997). 4.Porcari, A.R.,Devivar, R.V.,Kucera, L.S., et al. Design, synthesis, and antiviral evaluations of 1-(substituted benzyl)-2-substituted-5,6-dichlorobenzimidazoles as nonnucleoside analogues of 2,5,6-trichloro-1-(β-D-ribofuranosyl)benzimidazole. Journal of Medicinal Chemistry 41(8), 1252-1262 (1998). 5.Broder, S. The development of antiretroviral therapy and its impact on the HIV-1/AIDS pandemic. Antiviral Res. 85(1), 1-18 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 267.3 |
| 分子式 | C10H13N5O4 |
| CAS号 | 30516-87-1 |
| 稳定性 | ≥ 2 years |
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