LDN-57444
货号：
15396-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 15396-1mg |
| 描述 | The ubiquitin C-terminal hydrolase L1 (UCH-L1) is a member of a family of de-ubiquitinating enzymes that can generate free ubiquitin from ubiquitin precursors via its ubiquitin ligase activity. By associating with free ubiquitin, it also prevents its degradation. Neuronal UCH-L1 has been linked to Parkinson’s disease, the development of tumors, and neuropathic pain.1 LDN-57444 is an inhibitor of UCH-L1 activity (IC50 = 0.88, Ki = 0.4 μM) that demonstrates selectivity for UCH-L1 compared to UCH-L3 (IC50 = 25 μM).2 Loss of UCH-L1 activity causes cell death through the apoptosis pathway due to an impaired ubiquitin-proteasome pathway. LDN-57444-induced reduction of free ubiquitin has been shown to create dramatic alterations in synaptic structure and function, increasing spine size while decreasing spine density in hippocampal neurons.1 |
| 别名 | Ubiquitin C-terminal Hydrolase L1 Inhibitor;UCH-L1 Inhibitor; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Cartier, A.E.,Djakovic, S.N.,Salehi, A., et al. Regulation of synaptic structure by the ubiquitin C-terminal hydrolase UCH-L1. Journal of Neuroscience 29(24), 7857-7868 (2009).
2.Liu, Y.,Lashuel, H.A.,Choi, S., et al. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chemistry & Biology 10(9), 837-846 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 397.6 |
| 分子式 | C17H11Cl3N2O3 |
| CAS号 | 668467-91-2 |
| 稳定性 | ≥ 2 years |
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