STF-118804
货号：
15283-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 15283-1mg |
| 描述 | Nicotinamide phosphoribosyltransferase (Nampt) converts nicotinamide into nicotinamide mononucleotide (NMN), which is subsequently converted to NAD+ by NMN adenyltransferase. Cancer cells commonly have an unusually high rate of NAD+ turnover, suggesting that inhibition of Nampt might selectively target cancer cells. STF-118804 is a small molecule inhibitor of Nampt (IC50s = 3-6 nM) that prevents NAD+ synthesis from nicotinamide.1 It inhibits the viability of multiple B-cell acute lymphoblastic leukemia (B-ALL) cell lines with nanomolar potency and induces apoptosis in MV4-11 cells.1 At 50 mg/kg for 20 days, STF-118804 has been shown to improve survival in an orthotopic xenotransplant model of high-risk ALL in mice.1 It has also been shown to target leukemia stem cells.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Matheny, C.J.,Wei, M.C.,Bassik, M.C., et al. Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. Chemistry & Biology 20, 1352-1363 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 461.5 |
| 分子式 | C25H23N3O4S |
| CAS号 | 894187-61-2 |
| 稳定性 | ≥ 2 years |
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