PFI-3
货号：
15267-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 15267-1mg |
| 描述 | The SWI/SNF-related, Matrix-associated, Actin-dependent Regulator of Chromatin (SMARC) proteins integrate into complexes that remodel chromatin.1 The SMARC family A (SMARCA) members SMARCA2 (also known as BRM) and SMARCA4 (BRG1) are helicases that contain structurally-related bromodomains for binding acetylated lysine residues on target proteins.2,3 The protein polybromo-1 (PB1, BRG1-associated factor) contains six bromodomains, but only the fifth (PB1(5)) shares the same structural signature as those of SMARCA2 and SMARCA4.2 PFI-3 is a probe that binds avidly to the structurally-similar SMARCA4 bromodomain and PB1(bromodomain 5) with Kd values of 89 and 48 nM, respectively. Evaluation of interactions of PFI-3 with different classes of bromodomains using thermal stability assay indicates that PFI-3 interacts selectively with bromodomains from SMARCA2 and SMARCA4 as well as the fifth domain of PB1. Similarly, PFI-1 (Item No. 11155) does not interact with a panel of kinases. See the Structural Genomics Consortium (SGC) website for more information. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ring, H.Z.,Vameghi-Meyers, V.,Wang, W., et al. Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome. Genomics 51(1), 140-143 (1998).
2.Vidler, L.R.,Brown, N.,Knapp, S., et al. Druggability analysis and structural classification of bromodomain acetyl-lysine binding sites. Journal of Medicinal Chemistry 55(17), 7346-7359 (2012).
3.Park, J.I.,Venteicher, A.S.,Hong, J.Y., et al. Telomerase modulates Wnt signalling by association with target gene chromatin. Nature 460(7251), 66-72 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 321.4 |
| 分子式 | C19H19N3O2 |
| CAS号 | 1819363-80-8 |
| 稳定性 | ≥ 2 years |
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