ML-193
货号：
15184-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 15184-1mg |
| 描述 | ML-193 is a potent antagonist of GPR55 (IC50 = 221 nM).1,2 It displays selectivity for GPR55 over CB1, CB2, and GPR35. ML-193 inhibits GPR55-dependent ERK phosphorylation (IC50 = 65 nM) and blocks translocation of PKCβII.1 ML-193 blocks increases in intracellular calcium levels induced by lysophosphatidylinositol (LPI) in dissociated rat periaqueductal gray neurons and modulates pain perception in LPI-treated rats.3 |
| 别名 | CID-1261822; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Heynen-Genel, S.,Dahl, R.,Shi, S., et al. Screening for selective ligands for GPR55 - antagonists. NIH Mol.Libraries (2010).
2.Kotsikorou, E.,Sharir, H.,Shore, D.M., et al. Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry 52(52), 9456-9469 (2013).
3.Deliu, E.,Sperow, M.,Console-Bram, L., et al. The lysophosphatidylinositol receptor GPR55 modulates pain perception in the periaqueductal gray. Mol.Pharmacol. 88(2), 265-272 (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 527.6 |
| 分子式 | C28H25N5O4S |
| CAS号 | 713121-80-3 |
| 稳定性 | ≥ 2 years |
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