| 货号 | 15068-1g |
| 描述 | Trifluoperazine (TFP) is a phenothiazine compound with anti-adrenergic and anti-dopaminergic actions typical of antipsychotic agents. It antagonizes adrenergic receptors, with selectivity for α1 over the α2 subtypes (Kis = 24, 653, 163, and 391 nM for α1A, α2A, α2B, and α2C, respectively).1 TFP binds with much higher affinity to the dopamine D2-like receptor (Kd = 0.96 nM) compared to the dopamine D4-like and the serotonin 5-HT2A receptors (Kds = 44 and 135 nM, respectively).2 Furthermore, TFP antagonizes calmodulin (CaM) and alters the calcium-binding properties of calsequestrin (CSQ).3,4 TFP has been shown to activate type-2 ryanodine receptors independently of its CaM and CSQ activity.4 |
| 别名 | SKF 5019;TFP; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kroeze, W.K.,Hufeisen, S.J.,Popadak, B.A., et al. H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs. Neuropsychopharmacology 28(3), 519-526 (2003). 2.Seeman, P.,Corbett, R. and Van Tol, H.H. Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors. Neuropsychopharmacology 16(2), 93-110 (1997). 3.Zimmer, M. and Hofmann, F. Calmodulin antagonists inhibit activity of myosin light-chain kinase independent of calmodulin. European Journal of Biochemistry 142(2), 393-397 (1984). 4.Qin, J.,Zima, A.V.,Porta, M., et al. Trifluoperazine: A ryanodine receptor agonist. Pflugers.Arch. 458(4), 643-651 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 480.4 |
| 分子式 | C21H24F3N3S • 2HCl |
| CAS号 | 440-17-5 |
| 稳定性 | ≥ 2 years |
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