HPOB
货号：
15066-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 15066-1mg |
| 描述 | HPOB is a potent inhibitor of histone deacetylase 6 (HDAC6; IC50 = 56 nM).1 It is at least 30-fold less effective against other HDACs.1 Through its effects on HDAC6, HPOB induces acetylation of α-tubulin but not histones.1 HPOB reduces the growth, but not the viability, of normal and transformed cells.1 It enhances the death of transformed cells as triggered by the topoisomerase II inhibitors etoposide and doxorubicin.1 HPOB enhances the cytotoxicity of the broad spectrum HDAC inhibitor SAHA (Item No. 10009929) against cancer cells in nude mice carrying an androgen-dependent CWR22 human prostate cancer xenograft.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Fang, K.,Schlingmann, G.,Enos, A., et al. New biotransformation products of nemadectins. J.Antibiot.(Tokyo) 54(10), 805-809 (2001).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 314.3 |
| 分子式 | C17H18N2O4 |
| CAS号 | 1429651-50-2 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
