| 货号 | 15039-500mg |
| 描述 | The black seeds of Nigella have long been ingested to treat a broad range of diseases, including inflammation and cancer.1 Thymoquinone is a natural phytochemical isolated from the seeds of N. sativa.1 It has anti-inflammatory effects, blocking the synthesis of leukotrienes.2,1 Thymoquinone inhibits the growth of leukemia cells (IC50 = 1.5 μg/ml), inducing apoptosis by down-regulating the expression of Bcl-2 while up-regulating Bax expression.3 In addition to blocking cell proliferation and triggering apoptosis, thymoquinone (15 μM) suppresses STAT3-regulated gene expression and prevents angiogenesis.4,5 |
| 别名 | NSC 2228; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Randhawa, M.A. and Alghamdi, M.S. Anticancer activity of Nigella sativa (black seed) - A review. Am.J.Chin.Med. 39(6), 1075-1091 (2011). 2.Ragheb, A.,Attia, A.,Eldin, W.S., et al. The protective effect of thymoquinone, an anti-oxidant and anti-inflammatory agent, against renal injury: A review. Saudi J.Kidney Dis.Transpl. 20(5), 741-752 (2009). 3.Salim, L.Z.,Mohan, S.,Othman, R., et al. Thymoquinone induces mitochondria-mediated apoptosis in acute lymphoblastic leukaemia in vitro. Molecules 18(9), 11219-11240 (2013). 4.Banerjee, S.,Padhye, S.,Azmi, A., et al. Review on molecular and therapeutic potential of thymoquinone in cancer. Nutrition and Cancer 62(7), 938-946 (2010). 5.Li, F.,Rajendran, P. and Sethi, G. Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway. British Journal of Pharmacology 161(3), 541-554 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 164.2 |
| 分子式 | C10H12O2 |
| CAS号 | 490-91-5 |
| 稳定性 | ≥ 2 years |
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