PF-05274857 (hydrochloride)
货号：
15022-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 15022-1mg |
| 描述 | Sonic hedgehog (Shh) signaling is initiated by binding of the ligand, Shh, to the receptor Patched 1, which relieves suppression by the associated receptor Smoothened (Smo). PF-05274857 is an antagonist which binds Smo (Ki = 4.6 nM), blocking Gli1 transcription in cells stimulated with Shh (IC50 = 2.7 nM).1 When administered orally, it distributes through plasma to skin and tumor and remains metabolically stable. PF-05274857 also penetrates the blood-brain barrier and inhibits Smo activity in the brain. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Rohner, A.,Spilker, M.E.,Lam, J.L., et al. Effective targeting of hedgehog signaling in a medulloblastoma model with PF-5274857, a potent and selective smoothened antagonist that penetrates the blood-brain barrier. Molecular Cancer Therapeutics 11(1), 57-65 (2012).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 473.4 |
| 分子式 | C20H25ClN4O3S • HCl |
| CAS号 | 1613439-62-5 |
| 稳定性 | ≥ 2 years |
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