Doxorubicin (hydrochloride)
货号：
15007-5mg 基本售价：
350.0 元 规格：
5 mg
产品信息
概述| 货号 | 15007-5mg |
| 描述 | Doxorubicin is an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks.1 By intercalating within DNA, doxorubicin inhibits nucleic acid synthesis and induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein.2 |
| 别名 | Adriacin;DOX;NSC 123127; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Patel, S.,Sprung, A.U.,Keller, B.A., et al. Identification of yeast DNA topoisomerase II mutants resistant to the antitumor drug doxorubicin: Implications for the mechanisms of doxorubicin action and cytotoxicity. Mol. Pharmacol. 52(4), 658-666 (1997).
2.Lorenzo, E.,Ruiz-Ruiz, C.,Quesada, A.J., et al. Doxorubicin induces apoptosis and CD95 gene expressionin human primary endothelial cells through a p53-dependent mechanism. The Journal of Biological Chemisty 277(17), 10883-10892 (2002).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 580 |
| 分子式 | C27H29NO11 • HCl |
| CAS号 | 25316-40-9 |
| 稳定性 | ≥ 2 years |
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