| 货号 | 14975-100mg |
| 描述 | Stavudine is an analog of thymidine that, following phosphorylation by cellular kinases, inhibits the reverse transcriptase of human immunodeficiency virus.1,2,3 It is effective in vitroandin vivo, orally available, and additive in action with protease inhibitors.1,2,3 Adverse events associated with stavudine use include peripheral neuropathy, lactic acidosis, and pancreatitis.4 |
| 别名 | d4T;NSC 163661; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hamamoto, Y.,Nakashima, H.,Matsui, T., et al. Inhibitory effect of 2,3-didehydro-2,3-dideoxynucleosides on infectivity, cytopathic effects, and replication of human immunodeficiency virus. Antimicrobial Agents and Chemotherapy 31(6), 907-910 (1987). 2.Deminie, C.A.,Bechtold, C.M.,Stock, D., et al. Evaluation of reverse transcriptase and protease inhibitors in two-drug combinations against human immunodeficiency virus replication. Antimicrobial Agents and Chemotherapy 40(6), 1346-1351 (1996). 3.Mitsuya, H.,Yarchoan, R.,Kageyama, S., et al. Targeted therapy of human immunodeficiency virus-related disease. FEBS Journal 5, 2369-2381 (1991). 4.Murphy, R.A.,Sunpath, H.,Kuritzkes, D.R., et al. Antiretroviral therapy-associated toxicities in the resource-poor world: The challenge of a limited formulary. Journal of Infectious Diseases 196, S449-S456 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 224.2 |
| 分子式 | C10H12N2O4 |
| CAS号 | 3056-17-5 |
| 稳定性 | ≥ 2 years |
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