| 货号 | 14943-1mg |
| 描述 | 24-dehydro Cholesterol is an immediate precursor to cholesterol in the Bloch pathway of cholesterol biosynthesis. Structurally, it varies from cholesterol only by a single double bond at carbon 24 and has been used as cholesterol substitute in cellular membrane studies.1 During brain development, 24-dehydro cholesterol transiently accumulates, composing up to 30% of total brain sterol, where it is poised to rapidly enrich membrane sterols.2 However, defects in cholesterol synthesis can lead to a condition called, desmosterolosis, which results in an accumulation of excess 24-dehydro cholesterol.3 24-dehydro Cholesterol has been reported to activate liver X receptor-target genes in both the liver of cholesterol-free mice and in cholesterol-starved macrophage foam cells in atherosclerotic lesions.4,5 |
| 别名 | Desmosterol;NSC 226126; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Huster, D.,Scheidt, H.A.,Arnold, K., et al. Desmosterol may replace cholesterol in lipid membranes. Biophysical Journal 88(3), 1838-1844 (2005). 2.Jansen, M.,Wang, W.,Greco, D., et al. What dictates the accumulation of desmosterol in the developing brain? The FASEB Journal 27(3), 865-870 (2013). 3.Clayton, P.T. Disorders of cholesterol biosynthesis. Archives of Disease in Childhood 78(2), 185-189 (1998). 4.Heverin, M.,Meaney, S.,Brafman, A., et al. Studies on the cholesterol-free mouse: Strong activation of LXR-regulated hepatic genes when replacing cholesterol with desmosterol. Arteriosclerosis, Thrombosis, and Vascular Biology 27(10), 2191-2197 (2007). 5.Spann, N.J.,Garmire, L.X.,McDonald, J.G., et al. Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. Cell 151(1), 138-152 (2012). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 384.6 |
| 分子式 | C27H44O |
| CAS号 | 313-04-2 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |