| 货号 | 14941-1g |
| 描述 | Quinolinic acid is an endogenous agonist at NMDA receptors that is generated through the metabolism of tryptophan in the kynurenine pathway.1 By overactivating NMDA receptors, quinolinic acid produces neurotoxicity, which has been implicated in certain neurodegenerative disorders.2 Quinolinic acid can also generate reactive oxygen species, has immunomodulatory actions, and promotes the formation of hyperphosphorylated tau proteins.3,4,5 |
| 别名 | NSC 13127;NSC 18836;NSC 403247; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Heyes, M.P.,Achim, C.L.,Wiley, C.A., et al. Human microglia convert L-tryptophan into the neurotoxin quinolinic acid. Biochemistry Journal 320(2), 595-597 (1996). 2.Stone, T.W.,Forrest, C.M. and Darlington, L.G. Kynurenine pathway inhibition as a therapeutic strategy for neuroprotection. FEBS Journal 279 (8), 1386-1397 (2012). 3.Santamaría, A.,Santamaría, D.,Díaz-Muñoz, M., et al. Effects of N.Omega.-nitro-L-arginine and L-arginine on quinolinic acid-induced lipid peroxidation. Toxicology Letters 93, 117-124 (1997). 4.Moffett, J.R.,Espey, M.G. and Namboodiri, M.A.A. Antibodies to quinolinic acid and the determination of its cellular distribution within the rat immune system. Cell and Tissue Research 278, 461-469 (1994). 5.Stone, T.W.,Stoy, N. and Darlington, L.G. An expanding range of targets for kynurenine metabolites of tryptophan. Trends in Pharamacological Sciences 34(2), 136-143 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 167.1 |
| 分子式 | C7H5NO4 |
| CAS号 | 89-00-9 |
| 稳定性 | ≥ 2 years |
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