AG-1295
货号：
14529-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 14529-1mg |
| 描述 | Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors specific for platelet-derived growth factor (PDGF) receptor kinase could help in the treatment of atherosclerosis, restenosis, pulmonary fibrosis, and gliomas.1 AG-1295 is a quinoxaline-type tyrphostin that acts as a potent and selective inhibitor of PDGF receptor kinase in vitro and in Swiss 3T3 cells (IC50s range from 0.3-1 µM).2 It inhibits PDGF-stimulated DNA synthesis with an IC50 value of 2.5 µM without affecting activity of the EGF receptor.2 |
| 别名 | NSC 380341;Tyrphostin AG-1295; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Levitzki, A. and Gazit, A. Tyrosine kinase inhibition: An approach to drug development. Science 267(5205), 1782-1788 (1995).
2.Kovalenko, M.,Gazit, A.,Böhmer, A., et al. Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation. Cancer Research 54, 6106-6114 (1994).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 234.3 |
| 分子式 | C16H14N2 |
| CAS号 | 71897-07-9 |
| 稳定性 | ≥ 2 years |
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