Zinc Protoporphyrin-9
货号：
14483-10mg 基本售价：
350.0 元 规格：
10 mg
产品信息
概述| 货号 | 14483-10mg |
| 描述 | Zinc protoporphyrin-9 (ZnPPIX) is an endogenous metabolite formed during heme biosynthesis under conditions of iron insufficiency or impaired iron utilization.1 It also regulates heme catabolism through competitive inhibition of heme oxygenase, the rate-limiting enzyme in the heme degradation pathway that produces bilirubin and carbon monoxide.1 ZnPPIX has been shown to inhibit 80% of soluble guanylyl cyclase basal activity at 2.5 μM and to inactivate the NOS isoforms nNOS, iNOS, and eNOS with IC50 values of 0.8, 4, and 5 μM, respectively.2,3 ZnPPIX has been used to assess iron status and to diagnose iron disorders and has shown therapeutic potential in hyperbilirubinemia.1 |
| 别名 | ZnPPIX; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Labbé, R.F.,Vreman, H.J. and Stevenson, D.K. Zinc protoporphyrin: A metabolite with a mission. Clinical Chemistry 45(12), 2060-2072 (1999).
2.Serfass, L. and Burstyn, J.N. Effect of heme oxygenase inhibitors on soluble guanylyl cyclase activity. Archives of Biochemistry and Biophysics 359(1), 8-16 (1998).
3.Wolff, D.J.,Naddelman, R.A.,Lubeskie, A., et al. Inhibition of nitric oxide synthase isoforms by porphyrins. Archives of Biochemistry and Biophysics 333(1), 27-34 (1996).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 626 |
| 分子式 | C34H32N4O4Zn |
| CAS号 | 15442-64-5 |
| 稳定性 | ≥ 2 years |
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