| 货号 | 14422-1g |
| 描述 | Doxycycline (hyclate) is a tetracycline-like antibiotic which effectively controls or prevents a diverse array of infections, including anthrax, Lyme disease, malaria, and Brucellosis.1,2,3,4 In genetic engineering, doxycycline is used as the regulator for inducible gene expression systems, whereby expression depends on either the presence (Tet-On) or absence (Tet-Off) of doxycycline.5,6 Also, doxycycline inhibits certain matrix metalloproteinases (MMP), such as MMP-8 (Ki = 36 µM).7,8 It only poorly inhibits MMP-1 and MMP-13 (Ki > 100 µM).7 |
| 别名 | WC 2031; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hicks, C.W.,Sweeney, D.A.,Cui, X., et al. An overview of anthrax infection including the recently identified form of disease in injection drug users. Intensive Care Med. 38(7), 1092-1104 (2012). 2.Nau, R.,Christen, H.J. and Eiffert, H. Lyme disease--current state of knowledge. Dtsch.Arztebl.Int. 106(5), 72-81 (2009). 3.Steinhardt, L.C.,Magill, A.J. and Arguin, P.M. Review: Malaria chemoprophylaxis for travelers to Latin America. American Journal of Tropical Medicine and Hygiene 85(6), 1015-1024 (2011). 4.Solís Gracía del Pozo, J.S. and Solera, J. Systematic review and meta-analysis of randomized clinical trials in the treatment of human brucellosis. PLoS One 7(2), (2012). 5.Gould, D.J.,Berenstein, M.,Dreja, H., et al. A novel doxycycline inducible autoregulatory plasmid which displays “on”/“off” regulation suited to gene therapy applications. Gene Ther. 7(24), 2061-2070 (2000). 6.Li, Z.,Michael, I.P.,Zhou, D., et al. Simple piggyBac transposon-based mammalian cell expression system for inducible protein production. Proceedings of the National Academy of Sciences of the United States of America 110(13), 5004-5009 (2013). 7.Smith, G.N., Jr.,Mickler, E.A.,Hasty, K.A., et al. Specificity of inhibition of matrix metalloproteinase activity by doxycycline: Relationship to structure of the enzyme. Arthritis and Rheumatism 42(6), 1140-1146 (1999). 8.Griffin, M.O.,Ceballos, G. and Villarreal, F.J. Tetracycline compounds with non-antimicrobial organ protective properties: Possible mechanisms of action. Pharmacological Research 63(2), 102-107 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 1025.9 |
| 分子式 | 2[C22H24N2O8] • 2HCl • H2O • C2H6O |
| CAS号 | 24390-14-5 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |